tJ n r 1£1 I a '' u l't mm J - A 5 May 1955 A ion ot th Ros98l'oh end 0 91 c r cnt Prcero m ot TSS Clle ucal l idcic in is d'J'lotod ta the diacove17 of the tollowing ir aterielo c ul 111ethoda s 1 St 1bstanoea 11hich vill promote illo Iical tb1nkSng and impnlsivenes to tba point vhere the rooipicmt vould be 4iaer ted 1D pubUc · 2 Substances vbioh increase the etticieney ot menta - tion and perception 3 l- torials which will pro· ant w counteract tho intcxio til g otr ot·- ot aloonol 4 Matnials vM ch vill pro note the intoxioatin et eot ot alcohol • s M terJ ale lhich vill prod11c• the a1 end s pto a ot ncogni ecl c li D04Dos 1n a reversible vay eo that tho mq be used ror maliugerillg · 6 Materials 11hich vill render the induotion ot hypnosis euie - or othervi Do enhance its U4'etulness • 7 Substancea wioh vill enhance tho abilit7 ot ir t 1• Tidnala to vithatond privs tio i tol't' n-e and oooroion luring intffrozation GJ1d O-eailsci 11 braiu-w ahing11 • s Y a teriala and physical methoda vhich vill produoe amea1a to oventa precedillg ct lriz g tlwir UH 9 Phyoioal thods ot producing ohock and contusion ot ti le and capable ot surre titious OYel' mended pviod3 uae 10 Subat no3 wich produce pl 7sical cliaablemen u panqaia of the legs aaute nem1A eto _- 11110h _ - 0 - -- ' · · · ·'-C' f t • by I I tJ • ·•L J •j t • d 1tc •• •r IJ• 19 'Y 0• 187 '75 C - 77 • 1··1---- - · 1- i' cr ur -----ltl 473 · t RaEASED ·---- APR - - ··-'r•J t o 1993 · · - 1 t - er t 7 t·ia · ·• ·- -- ·---- HOOo - --------- 11 B- ibotancoo vbioh vill produoe 11pt tre ouphona vi th no subSCJqUent lot-dew 12 Bubstanoeo vhieb alter poroonallty st1'UOture in auob vq thnt the t mdency ot tho recipient to become dependent upcm another per on is onhnnced • 13• A n a tori tl ihich uil1 c UUJe lll6 ltal cont V ion ot auoh a type th c Lt the in ividual cr tlcr ito Wlumce • dll find it dii'tioult to m unttnn o i'c briOAtion under que tionillg 14 Substances vhioh vill lC ' t r tho e t1biticn and ganeral vorking e fioicnO ot i n when admlniotered 1n undeteotabla amounta 15 Sub Jtc nces vhich promota veslmeso or d1otortion oye il ht or he 1ring i'c cultiea pro erob q vithout perman'Jllt of-tocts ot the 16 A knockcut pill vhich c m curreptitiously bo adm1n1 torcd 1n Grillk fe-od o1garettes c9 an cercsol etc uhieh 1- -ill bo n-u o to WJe provide a l' Xl'i r um ot moa 4 c - be cui l ror uc3 bf ent tn eo on en e d hc J basis 17 A nat61 1al which co n be aurroptiticu ly odm1n1s- tored b7 tho above routes ond vhieh in ver- c v il1 e r ounts v-lll n nke it kpoo3ible tor a mo n to perform Ml p oioal aotirlty 11hatever The development ot cateria J e ot this type follow a the stt ndo rd pmc tice ot such ethico l ti - g hounoa o o j It ia a rulativoly l Outino proeeduro to de olop a to the point ot hUJUU1 3ting Ol·dinaril 7 tha drug hc1 tn9G depend · upon tbs t1c-nioea ot private ph fdoinna tor t1 '3 finnl cliniou teating rne p dcians nro v1 lllng to acS1 U o the ro on«1ibil1t7 ot OU' l tests in c rder to e dvance tho acicnt e ot medioi -1 It · I I is d 1f't101 1lt and oo r etir lea icpossible tor TSS CD to ofter auch an induoc mt With t'onpcct to it a produote In p oactice it bu been possible to use out side olcil ecl contractors tor th8 prE'l1n 1na17 phasao ot th1a uo k Ho- -nor th- t pm vhich involvsa hu t m tootin« at ei'teotive dose levela presento 00CU1'1t7 problems vhioh 041U10t handled by the ordinal·y contractor J I i D T CL liY 107•i7G J1 ·· 1 • • cfs l ' - 75 - - - - - - • f U 1 61 I _ _ 187-i'l JZ '1'he proposed fo l ilit1 otters a unique OJY POZ'• tunit7 tor tho aoaure ban1J1na or eucn olinicsl tosting in e c141ticm to the D' ltl1 adv eo outlined in tho proJeo-t prol'C aal 'l'bo oecurity prob ntioned above ore Jfo1o t od bf the tact that the 1•o nsibillt1 tor too testing till reat co t 9letely upon the phyaiofo n Mil tbo hoapi tal r ort iJMs to supama th11 ork ver c ao to we euro that all tost aro conducted according to the recognized pmoticos c nd embody lequate _sa 1 oguard3 mll cl lov --· •4-·----·-·--l ---- · • l • ·• I 41 4 C I 'J I J - ANNOTATED VERSION FOLLOWS 35-l -i · • - -- - - • 5 y A 1555 A 'ticn er th Ra s ch and _De- elc 7- Cnt Prcgre n or TSS Cr - J cl Oi·ticion ia d voted t the ci co -er r cf t lo o1 l7 1ing l 9 ta 1' c 1d m a·chods - 2 Subatancas which illcrea e the ef'£ic1eney 0£ e n tion and parcepticn 3 - at3 -ia13 which ' Jill prGvsnt or cow1teraet 3 intc ic l ti -c Gf'i 3 t- slcoilol 4 Materials Yhich will pro nota the into d catir at ect ol c1 eohol 1 - ' i 5 V ateria 1e vhicll -ill pro faca the s i eud or racog rl 3ad cH 3-3 iea in a -evarsibl li-ay be used i'or maJ 1 1gerir g otc 1 1 20 Sj t ' G that th07 · • S'' - y 6 Me te1 G hich will r lc 9r the indaotion o bnmosis ea sis or otller dDe enhs nce its 1 1e1 esa - 7 Substs J e - hich uill en ' 9 Ilca tho ability- of di ' ' vid s to vithstmld p -i tio i tort- a and 0oerc 0u l ing interrc -l timi sr 1 x -callsd z bre i n- ruhing 8 V at rial 3 nnd physicsl atho- i s which uill prOQ Uce meah tor avent3 proc c - ring t -1 -•ir uso 9 Phyoical 'ra 3thoru or proe ucr1 g ciiock e nd ccn 1 tiion over Cl tend period 0£ ti s icd pable ct su -r tit cu s tWa 10 Subst 3llC3 l which prod ice p1V 1icu dioablezr ent auch as paralynis or tha legs e cute ne iiA etc ' - - •--- - 1 • ··•- _ -- - t - - - - L · • · C - _ •• • 1 - • - 75 --- ' # · ' - 1 • _ _ 1 · •· · •- - •-J tc r i __ r of l ' •17 5 •• J __ n S- ibotcncoe which vi l prodt oe pureu- cupbcriA vith no c ubscquent let-dew'll 12 Subat 5 nee t hiob al· er porso i alit r structure in cu ob r _V t t the c eney 0£ tc recipient to bacc 18 depondent en another pa1· c 1 s onh mc--d• _ _ 13 J rc tori - l i'hich ui l c _uae t le ltal co t ' Usi n ot m oh a typa tbt tha inci ivic l i'J l t or ita Wluencs '111 L ld it dli'ria- l t to mintaL a f brieaticn maer q_'U e tioning I 14 Sub3tallecs 'Which Y12l J r tho epbitic i cl gC ls v t r ng e 'icie nC or en l han ao · n ltared 1n lm datc-otabla e 0' mta 15 Subat mces l hich pr ts xeµness or fil at ' rt1 o o e t th I oye i ht o lle il ing le c -ulties proi'e bq vithcut r e1 z ai_it1 S ei-J ec tr 16 A knockcut pill wbiC l c m curreptitiOW ly bo adm1n1starci in e ri lk t oed oigarettes es mi c eroaol etc uhich tl 11 be s o to Wid provide a t a' 't u l o t'tt-'i A 1 ba suit bl er t 3 cy e lt -e J C l e u ad hoo basis 17 A n ' t ial llhich cnn be GUITOptiticu sly f'dmin1 at red b7 the nbo--ve routea end vhich in VG'r7 c m l a ts vill t ' Ske it a ible fer a I Ul to par o -m 8IJ j p cical activity t' atEWer• · The devalop 1ent ot r ateriels or this typ3 f'ollo- ta t a _ at ' d rd pr otic3 or tuch ethictl c g hou o C ZJ - -l tll It is a lat - -el r r u- prcced u -e t'J dt al- p i a Ug to the point of h test fng C rfil - aril 7 th3 d -ug hC'l ln G c pend upo tho s oas ct priv ta p 7 ici llls fer tt fil tl elin CJ l ts6ti g na phy oinn3 c ro JHng to a S o o the ro onsibility or 3'J h t sta in crocr t-o dv - e tho sci e of medicine It J1 is cll ' i 'J l t e ld so7 eti e9 il pc sible or TSS CD to off r cuch F n ducc nt ldth ro cct to ita prcduots In i -sctica i t b en possible to us3 out ic 3 cl a ·ed contmct'1rs £or ths preJ i 1n£-1 7 p' b j ao of this ' o 'k Ho• rvor t - t p -t w fch involvaa h n test at ef£zoti e do3e leve1o preaanto c c- irity pl'Oblet ZS vhioh o t b h dlsd c r tha o 7 ccn --e ctor • ' tv · · • i t t t ft I- 0 • -i 137• · -5 - - - -·------1 --·--· - J - ' ' _· o - ··# 'I •••• · • - l ' I - _ • _ ___ _ -_-_- ___ _c_r _ _ v- -1-8- - 1- 7 - 3- il t- 1 c J c1 - • The pro oaed facility o f f r a e unique oppcrtt t 7 to- t-h9 S C J 1'9 b - zvlJ t z 01 · cil cJJ nic ll ta t1 ng b ditio to the ny ed' u n tagos cutlined in tho project propo U l Tho e eeurity p -cblm S nticne-l a e era eJ r iP'lti d by t -o t ct that th9 roc -onsibi 1 t7 for tha t sting - rill rest cc letol7 upon th9 p oicisn c nd the h spital • T I J l - l i l l c llo- i · · J p r c cl to G 3 a tha or t ve -y c i osoq to n e ko et Z O that all tosts or condue d 2-ccordi c g to the reec J z€d pr--ctices d c -n ody eci equo te _e a foguard3 1 I • o ' ·- · I t I i I ii I I I I I I' I I II l lI ·- I f l ' - IS